Publications

View full list of publications by the Maureen Su Lab

Bustillos CG, Peluso EM, Cha SL, Lechner MG, Su, MA. Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti-Cancer Immunity Across the Lifespan. Immunol Rev. 2026 Mar;24;338(1):e70096. doi: 10.1111/imr.70096 PMID: 41580387 PMCID: PMC12831719 

Chen HC, Bang MF, Wang HH, Shpargel KB, Kohn LA, Sailer D, Zhang S, McCarthy EC, Seyedsadr M, Stevens S, Pham CL, Zhou Z, Yin X, Wilkinson NM, Peluso EM, Bustillos C, Ortega JG, Yang L, Buzzelli AA, Capati RC, Chia DJ, Mittelman SD, Reh CM, Whitmire JK, Lechner MG, Hugo W, Su MA. UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes. J Clin Invest. 2025 Dec 16;136(4):e196325. doi: 10.1172/JCI196325. PMID: 41401033; PMCID: PMC12904725.

​Cheng MI, Hong L, Bustillos C, Chen B, Chin S, Luthers CR, Vo A, Sheikh SZ, Su MA. Cutting Edge: Hypoxia Sensing by the Histone Demethylase UTX (KDM6A) Limits Colitogenic CD4+ T Cells in Mucosal Inflammation. J Immunol. 2024 Apr 1;212(7):1069-1074. doi: 10.4049/jimmunol.2300550 PMID: 38353647 PMCID: PMC10948288

Su MA. JAK Inhibition Immunotherapy for APS-1. N Engl J Med. 2024 May 30;390(20):1918-1921.doi: 10.1056/NEJMe2403419 PMID: 38810191 

Seyedsadr M, Bang MF, McCarthy EC, Zhang S, Chen HC, Mohebbi M, Hugo W, Whitmire JK, Lechner MG, Su MA. A pathologically expanded, clonal lineage of IL-21-producing CD4+ T cells drives inflammatory neuropathy. J Clin Invest. 2024 Jun 11;134(15):e178602. PMID: 39087473 PMCID: PMC11290969 DOI: 10.1172/JCI178602

Lechner MG, Zhou Z, Hoang AT, Huang N, Ortega J, Scott LN, Chen HC, Patel AY, Yakhshi-Tafti R, Kim K, Hugo W, Famini P, Drakaki A, Ribas A, Angell TE, Su MA. Clonally expanded, thyrotoxic effector CD8+ T cells driven by IL-21 contribute to checkpoint inhibitor thyroiditis. Sci Transl Med. 2023 May 17;15(696):eadg0675. doi: 10.1126/scitranslmed.adg0675. Epub 2023 May 17. doi: 10.1126/scitranslmed.adg0675 PMID: 37196065 PMCID: PMC10227862 

Ding L, Sun L, Bu MT, Zhang Y, Scott LN, Prins RM, Su MA, Lechner MG, Hugo W. Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors. Front Immunol. 2023 Jun 26;14:1176994. doi: 10.3389/fimmu.2023.1176994 PMID: 37435085 PMCID: PMC10330698 

Cheng MI, Li JH, Riggan L, Chen B, Tafti RY, Chin S, Ma F, Pellegrini M, Hrncir H, Arnold AP, O'Sullivan TE, Su MA. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences. Nat Immunol. 2023 May;24(5):780-791. doi: 10.1038/s41590-023-01463-8 PMID: 36928413 PMCID: PMC12882737 

Quandt Z, Kim S, Villanueva-Meyer J, Coupe C, Young A, Kang JH, Yazdany J, Schmajuk G, Rush S, Ziv E, Perdigoto AL, Herold K, Lechner MG, Su MA, Tyrrell JB, Bluestone J, Anderson M, Masharani U. Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor-Induced Hypophysitis. J Endocr Soc. 2023 Feb 6;7(4):bvad012. doi: 10.1210/jendso/bvad012 PMID: 36860908 PMCID: PMC9969737 

Valenzise M, Foti Randazzese S, Toscano F, Lombardo F, Salzano G, Pajno C, Wasniewska M, Cascio A, Su MA. Mild COVID-19 in an APECED Patient with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and High Titer of Type 1 IFN-Abs: A Case Report. Pathogens. 2023 Mar 2;12(3):403. doi: 10.3390/pathogens12030403 PMCID: PMC10052931  PMID: 36986325 

Mandy I. Cheng, Luke Riggan, Joey H. Li, Rana Yakhshi Tafti, Scott Chin, Feiyang Ma, Matteo Pellegrini, Haley Hrncir, Arthur P. Arnold, Timothy E. O’Sullivan, Maureen A. Su. Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX. Preprint. **Highlighted by Nature Reviews Immunology "Preprint Watch: XXtra Killer Cells"

Lechner MG, Cheng MI, Patel AY, Hoang AT, Yakobian N, Astourian M, Pioso MS, Rodriguez ED, McCarthy EC, Hugo W, Angell TE, Drakaki A, Ribas A, Su MA. Inhibition of IL-17A Protects against Thyroid Immune-Related Adverse Events while Preserving Checkpoint Inhibitor Antitumor Efficacy. J Immunol. 2022 Aug 15;209(4):696-709. doi: 10.4049/jimmunol.2200244. Epub 2022 Jul 11. PMID: 35817515; PMCID: PMC9378719.

Wang Y, Guo L, Yin X, McCarthy EC, Cheng MI, Hoang AT, Chen HC, Patel AY, Allard Trout D, Xu E, Yakobian N, Hugo W, Howard JF Jr, Sheu KM, Hoffmann A, Lechner MG, Su MA. Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2114406119. doi: 10.1073/pnas.2114406119. PMID: 35058362.

Dasgupta A, Tsay E, Federman N, Lechner MG, Su MA. Polyendocrine Autoimmunity and Diabetic Ketoacidosis Following Anti-PD-1 and Interferon α. Pediatrics. 2022 Apr 1;149(4):e2021053363. doi: 10.1542/peds.2021-053363. PMID: 35274131; PMCID: PMC9804498.

Wilkinson NM, Chen HC, Lechner MG, Su MA. Sex Differences in Immunity. Annu Rev Immunol. 2022 Apr 26;40:75-94. doi: 10.1146/annurev-immunol-101320-125133. Epub 2022 Jan 5. PMID: 34985929; PMCID: PMC9805670.

Chou WC, Guo Z, Guo H, Chen L, Zhang G, Liang K, Xie L, Tan X, Gibson SA, Rampanelli E, Wang Y, Montgomery SA, Brickey WJ, Deng M, Freeman L, Zhang S, Su MA, Chen X, Wan YY, Ting JP. AIM2 in regulatory T cells restrains autoimmune diseases. Nature. 2021 Mar;591(7849):300-305. doi: 10.1038/s41586-021-03231-w. Epub 2021 Jan 27. Erratum in: Nature. 2021 Apr;592(7856):E29. doi: 10.1038/s41586-021-03490-7. Erratum in: Nature. 2025 Dec;648(8092):E4. doi: 10.1038/s41586-025-09859-2. PMID: 33505023; PMCID: PMC8080937.

Kathuria-Prakash N, Mosaferi T, Xie M, Antrim L, Angell TE, In GK, Su MA, Lechner MG. COVID-19 Outcomes of Patients With Differentiated Thyroid Cancer: A Multicenter Los Angeles Cohort Study. Endocr Pract. 2021 Feb;27(2):90-94. doi: 10.1016/j.eprac.2020.12.013. Epub 2021 Jan 4. PMID: 33551317; PMCID: PMC7831810.

Wolbert J, Cheng MI, Meyer zu Horste G, Su MA. Deciphering immune mechanisms in chronic inflammatory demyelinating polyneuropathies. JCI Insight. 2020 Feb 13;5(3):e132411. doi: 10.1172/jci.insight.132411. PMID: 32051341; PMCID: PMC7098793.​

Hwang BJ, Zhang Y, Brozowski JM, Liu Z, Burette S, Lough K, Smith CC, Shan Y, Chen J, Li N, Williams S, Su M, Googe P, Thomas NE, Liu Z. The dysfunction of BP180/collagen XVII in keratinocytes promotes melanoma progression. Oncogene. 2019 Dec;38(50):7491-7503. doi: 10.1038/s41388-019-0961-9. Epub 2019 Aug 21. PMID: 31435021; PMCID: PMC6908749.

Su MA, Anderson MS. Pulling RANK on Cancer: Blocking Aire-Mediated Central Tolerance to Enhance Immunotherapy. Cancer Immunol Res. 2019 Jun;7(6):854-859. doi: 10.1158/2326-6066.CIR-18-0912. PMID: 31160305; PMCID: PMC6550349.

Brown MA, Su MA. An Inconvenient Variable: Sex Hormones and Their Impact on T Cell Responses. J Immunol. 2019 Apr 1;202(7):1927-1933. doi: 10.4049/jimmunol.1801403. PMID: 30885988; PMCID: PMC6425974.

Liu C, He H, Li X, Su MA, Cao Y. Dynamic metrics-based biomarkers to predict responders to anti-PD-1 immunotherapy. Br J Cancer. 2019 Feb;120(3):346-355. doi: 10.1038/s41416-018-0363-8. Epub 2018 Dec 27. Erratum in: Br J Cancer. 2019 Apr;120(7):772. doi: 10.1038/s41416-019-0418-5. PMID: 30587849; PMCID: PMC6353899.

Allard DE, Wang Y, Li JJ, Conley B, Xu EW, Sailer D, Kimpston C, Notini R, Smith CJ, Koseoglu E, Starmer J, Zeng XL, Howard JF Jr, Hoke A, Scherer SS, Su MA. Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment. J Clin Invest. 2018 Oct 1;128(10):4727-4741. doi: 10.1172/JCI99308. Epub 2018 Sep 17. PMID: 30222134; PMCID: PMC6159985.

Zhang Y, Hwang BJ, Liu Z, Li N, Lough K, Williams SE, Chen J, Burette SW, Diaz LA, Su MA, Xiao S, Liu Z. BP180 dysfunction triggers spontaneous skin inflammation in mice. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6434-6439. doi: 10.1073/pnas.1721805115. Epub 2018 Jun 4. PMID: 29866844; PMCID: PMC6016813.

Smith CJ, Allard DE, Wang Y, Howard JF Jr, Montgomery SA, Su MA. IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4⁺ T Cell Migration. J Immunol. 2018 Mar 1;200(5):1580-1592. doi: 10.4049/jimmunol.1701280. Epub 2018 Jan 24. PMID: 29367208; PMCID: PMC5821539.

Bakhru P, Zhu ML, Wang HH, Hong LK, Khan I, Mouchess M, Gulati AS, Starmer J, Hou Y, Sailer D, Lee S, Zhao F, Kirkwood JM, Moschos S, Fong L, Anderson MS, Su MA. Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity. JCI Insight. 2017 Sep 21;2(18):e93265. doi: 10.1172/jci.insight.93265. PMID: 28931755; PMCID: PMC5621898.

Zhu ML*, Bakhru P*, Conley B, Nelson JS, Free M, Martin A, Starmer J, Wilson EM, Su MA. Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator. Nat Commun. 2016 Apr 13;7:11350. doi: 10.1038/ncomms11350. PMID: 27072778; PMCID: PMC5512610. *Shared authorship

Thrasher BJ, Hong LK, Whitmire JK, Su MA. Epigenetic Dysfunction in Turner Syndrome Immune Cells. Curr Allergy Asthma Rep. 2016 May;16(5):36. doi: 10.1007/s11882-016-0612-y. PMID: 27039394; PMCID: PMC4853915.

Anderson MS, Su MA. AIRE expands: new roles in immune tolerance and beyond. Nat Rev Immunol. 2016 Apr;16(4):247-58. doi: 10.1038/nri.2016.9. Epub 2016 Mar 14. PMID: 26972725; PMCID: PMC4831132.

Bakhru P, Su MA. Estrogen turns down "the AIRE". J Clin Invest. 2016 Apr 1;126(4):1239-41. doi: 10.1172/JCI86800. Epub 2016 Mar 21. PMID: 26999606; PMCID: PMC4811114.

Cook KD, Shpargel KB, Starmer J, Whitfield-Larry F, Conley B, Allard DE, Rager JE, Fry RC, Davenport ML, Magnuson T, Whitmire JK, Su MA. T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX. Immunity. 2015 Oct 20;43(4):703-14. doi: 10.1016/j.immuni.2015.09.002. Epub 2015 Sep 29. PMID: 26431949; PMCID: PMC4731234.

Su MA, Anderson MS. Breaking through the central tolerance ceiling to unleash anticancer immune responses. Oncoimmunology. 2014 Aug 3;3(8):e950169. doi: 10.4161/21624011.2014.950169. PMID: 25610739; PMCID: PMC4292738.

Whitfield-Larry F, Felton J, Buse J, Su MA. Myeloid-derived suppressor cells are increased in frequency but not maximally suppressive in peripheral blood of Type 1 Diabetes Mellitus patients. Clin Immunol. 2014 Jul;153(1):156-64. doi: 10.1016/j.clim.2014.04.006. Epub 2014 Apr 21. PMID: 24769355.

Khan IS, Mouchess ML, Zhu ML, Conley B, Fasano KJ, Hou Y, Fong L, Su MA, Anderson MS. Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance. J Exp Med. 2014 May 5;211(5):761-8. doi: 10.1084/jem.20131889. Epub 2014 Apr 21. PMID: 24752296; PMCID: PMC4010907.

Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS. The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol. 2014 Mar;15(3):258-65. doi: 10.1038/ni.2820. Epub 2014 Jan 26. Erratum in: Nat Immunol. 2014 Sep;15(9):894. PMID: 24464130; PMCID: PMC4172453.

Sarantopoulos S, Su MA. BAFF-ling autoantibodies. J Clin Invest. 2013 Dec;123(12):5006-8. doi: 10.1172/JCI73166. Epub 2013 Nov 25. PMID: 24270413; PMCID: PMC3859400.

Misumi I, Alirezaei M, Eam B, Su MA, Whitton JL, Whitmire JK. Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection. J Immunol. 2013 Dec 1;191(11):5655-68. doi: 10.4049/jimmunol.1301215. Epub 2013 Oct 21. PMID: 24146043; PMCID: PMC3879805.

Free ME, Bunch DO, McGregor JA, Jones BE, Berg EA, Hogan SL, Hu Y, Preston GA, Jennette JC, Falk RJ, Su MA. Patients with antineutrophil cytoplasmic antibody-associated vasculitis have defective Treg cell function exacerbated by the presence of a suppression-resistant effector cell population. Arthritis Rheum. July 2013; 65(7):1922-33.

Zeng Xiaopei L., Nagavalli Anil, Smith Colin-Jamal, Howard James F., Su Maureen A. Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by aire deficiency. Journal of Immunology. April 15 2013; 190(8): 3895-3904.

Free Meghan E., Bunch Donna O., McGregor JulieAnne, Britta Jones E., Berg Elisabeth A., Hogan Susan L., Hu Yichun, Preston Gloria A., Jennette J. C., Falk Ronald J., Su Maureen A. ANCA-associated vasculitis patients have defective Treg function exacerbated by presence of a suppression-resistant effector population. Arthritis & Rheumatism. April 1 2013.

Zhu Meng-Lei, Navagalli Anil, Su Maureen A. Aire deficiency promotes TRP-1 specific immune rejection of melanoma. Cancer Research. April 1 2013; 73(7): 2104-2116.

Su Maureen A.*, Davini Dan, Giang Karen, Fan Una, DeVoss Jason J., Johannes Kellsey P.A., Shum Anthony K., Valenzise Mariella, Veloni Antonella, Bour-Jordan Helene, and Anderson Mark S.* Defective Aire-Dependent Central Tolerance to P0 Predisposes to Autoimmune Peripheral Neuropathy. Journal of Immunology. May 2012; 188: 4906-4912. *Shared senior authorship. **Selected for “In This Issue” article, which highlights articles among top 10% of journal articles

Wang Yunqi, Su Maureen A, and Wan Yisong Y. An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity. Sep 2011; 35(3):337-48.

Anderson Mark S and Su Maureen A. Aire and T cell Development. Current Opinions in Immunology, Apr 2011; 23(2):198-206.

Su Maureen A and Anderson Mark S. Monogenic Autoimmune Diseases: Insights into the Immune System. Pediatric Research, 2009 May; 65(5 Pt 2):20R-25R.

Su Maureen A, Stenerson Matthew, Liu Weihong, Putnam Amy, Conte Felix, Bluestone Jeffrey A, and Anderson Mark S. The Role of X-linked FOXP3 in the Autoimmune Susceptibility of Turner Syndrome Patients. Clinical Immunology, Apr 2009, 131(1):139-44.

Louvet Cedric, Kabre Beniwende, Davini Dan, Martinier Nicolas, Su Maureen A, Devoss Jason, Rosenthal Wendy, Anderson Mark S., Bour-Jordan Helene, and Bluestone Jeffrey A. A novel myelin P0-specific T cell receptor transgenic mouse develops fulminant autoimmune peripheral neuropathy. Journal of Experimental Medicine, Mar 16 2009, 206(3): 507-14.

Gardner James M, Devoss Jason J, Friedman Rachel S, Wong David J, Tan Ying X, Zhou Xuyu, Johannes Kellsey P, Su Maureen A, Chang Howard Y, Krummel Matthew F, Anderson Mark S. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science, Aug 8, 2008;321(5890):843-7.

Su Maureen A, Giang Karen, Zumer Kristina, Jiang Huimin, Oven Irena, Rinn John L, Devoss Jason J, Johannes Kellsey P, Lu Wen, Gardner James, Chang Angela, Bubulya Paula, Chang Howard Y, Peterlin B Matija, Anderson Mark S. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. Journal of Clinical Investigation, May, 2008; 118(5):1712-26. *Featured as Cover Article “Walking on Aire.”

Zhang Li, Barker Jennifer M, Babu S, Su Maureen, Stenerson Matthew, Cheng Mickie, Shum Anthony, Zamir Ehud, Badolato Raffaele, Law Adam, Eisenbarth George S, Anderson Mark S. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clinical Immunology, Nov, 2007; 125(2):131-7.

Sipe Walter E, Su Maureen, Posselt Andrew, Kim Grace E, Quiros Jose A, Rosenthal Philip. Propylthiouracil-associated liver failure presenting as probable autoimmune hepatitis in a child with Graves’ disease. Pediatric Transplantation, Jun 2006;10(4):525-8.

Su Maureen A, Anderson Mark S. Aire: an update. Current Opinions in Immunology, Dec 2004;16(6):746-52.